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Congo Red

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Purity:98.1%

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COA HNMR HPLC

Congo Red

Catalog No. T14996Cas No. 573-58-0

Congo Red (Direct Red 28) is an azo dye. It binding been used as a diagnostic test for the presence of amyloid in tissue sections.

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Pack Size	Price	Availability
500 mg	$58	In Stock
1 g	$88	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Product Introduction

Bioactivity

Description	Congo Red (Direct Red 28) is an azo dye. It binding been used as a diagnostic test for the presence of amyloid in tissue sections.
In vitro	Congo Red histochemical stain may serve as a simple tool to investigate if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures[1]. Congo Red histochemical dye is able to bind specifically to crossed β-pleated sheet structures. Wild-type HSPB1 should maintain protein homeostasis by binding proteins in non-native conformations, thereby preventing substrate aggregation. The T139M mutant, however, fails in this function and results in an accumulation of misfolded proteins, which are targeted by Congo Red for intercalating between the β-pleated sheet structures.
Alias	Direct Red 28

Chemical Properties

Molecular Weight	696.66
Formula	C32H22N6Na2O6S2
Cas No.	573-58-0

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (143.54 mM)

H2O: 4.16 mg/mL (5.97 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4354 mL	7.1771 mL	14.3542 mL	71.7710 mL
5 mM	0.2871 mL	1.4354 mL	2.8708 mL	14.3542 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1435 mL	0.7177 mL	1.4354 mL	7.1771 mL
20 mM	0.0718 mL	0.3589 mL	0.7177 mL	3.5886 mL
50 mM	0.0287 mL	0.1435 mL	0.2871 mL	1.4354 mL
100 mM	0.0144 mL	0.0718 mL	0.1435 mL	0.7177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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